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Functional Overview of the Biotechnology Industry • To accompany Building Biotechnology ISBN 9780973467666 For more information: Yali Friedman, Ph.D. info@thinkbiotech.com www.BuildingBiotechnology.com • Relevant pages are cited within presentation • Type CTRL CTRL-L L to toggle fullscreen view Presentation starts on next page Functional Overview of the Biotechnology Industry Presentation to accompany BUILDING BIOTECHNOLOGY www.BuildingBiotechnology.com Objectives • Appreciate the diversity of biotechnology applications and the fundamentals of biotechnology • Distinguish biotechnology from ‘traditional’ traditional pharmaceuticals • Understand the value proposition of biotechnology companies • Appreciate i why h d drugs are the h most common application li i of biotechnology • Appreciate the interplay of legal, regulatory, and commercial factors The Pillars of Biotechnology Scientific Abilities Intellectual p y Property Commercial Bi t h l Biotechnology Regulations Commercial Factors What do Biotechnology Companies do? BUILDING BIOTECHNOLOGY Chp 6 Use molecular biology to develop useful products and services Drugs, diagnostic tests RED • Large profit margins • FDA mandates that all drugs must be proven safe and effective prior to marketing • History of successful regulation GREEN Enhanced crops, molecular farming (non-drug) • No regulatory legacy • Development costs similar to drugs, profits are not Industrial processes WHITE production waste degradation degradation, environmental remediation • Energy production, • Unresolved safety concerns, and issues in scalability Ecology Æ Physiology Æ Molecular Biology Source: EPA Ecology Æ Physiology Æ Molecular Biology NIST Ecology Æ Physiology Æ Molecular Biology Ecology Æ Physiology Æ Molecular Biology What is Molecular Biology? BUILDING BIOTECHNOLOGY Chp 3 Molecular biology is the study of biological processes at their most fundamental level Groups of bodies Ecology • Species and groups of animals, plants, and microbes Parts of bodies Physiology, botany, microbiology (virology) • Tissues • • • Organs The structures that compose animals, plants, and microbes How these structures interact with each other and the environment • • Individual cells Eg. Pharmacology, neurology, immunology Molecular biology Parts of cells • Large L and d • • small molecules Parts of molecules Parts of atoms The chemical and physical interactions within individual cells processes that underlie p physiology, y gy, botany, y, etc. The p Eg. What distinguishes heart from hair cells? How is food processed into energy and physiological structures? How do signals from the environment cause biological responses? Chemistry & Physics • The processes that form the basis for molecular biology